Trans-sodium crocetinate increases oxygen delivery to brain parenchyma in rats on oxygen supplementation.
Neurosci Lett
; 352(2): 97-100, 2003 Dec 04.
Article
em En
| MEDLINE
| ID: mdl-14625032
ABSTRACT
Trans-sodium crocetinate (TSC) is a vitamin A-analog that increases diffusivity of oxygen in aqueous solutions, including plasma. The current study is the initial investigation of the effects of TSC on oxygen delivery to brain. Adult male rats were intubated and ventilated with 21%, 60%, or 100% oxygen. A craniotomy was performed and a Licox rat brain tissue PO(2) probe inserted into parietal cortex. Rats were then administered intravenous infusions of either TSC or saline and brain tissue PO(2) values were recorded. TSC significantly increased brain tissue oxygen delivery. This effect was minimal in rats ventilated with normal air and substantial in rats on oxygen supplementation. Arterial blood gas parameters did not differ within groups. These results provide clear indication to study the utility of TSC in ameliorating hypoxic/ischemic insults in neurological disorders.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Consumo de Oxigênio
/
Oxigenoterapia
/
Vitamina A
/
Encéfalo
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Estados Unidos