Association of MICA polymorphism with rheumatoid arthritis patients in Koreans.
Hum Immunol
; 64(12): 1190-4, 2003 Dec.
Article
em En
| MEDLINE
| ID: mdl-14630402
ABSTRACT
To investigate whether genetic variations of MICA are associated with susceptibility to rheumatoid arthritis (RA), the (GCT)n microsatellite polymorphism of the transmembrane domain was analyzed in 144 Korean patients with RA and in 297 unrelated healthy controls. The allele frequency of MICA*A9 significantly decreased in RA patients compared with controls (9.0% vs. 15.3%, odds ratio [OR] = 0.55, p = 0.0098, p(c) = 0.049), whereas the frequency of the MICA*A4 and MICA*A5.1 alleles tended to increase in RA patients (21.2% vs. 14.8%, OR = 1.55, p = 0.018, p(c) > 0.05; 20.5% vs. 15.0%, OR = 1.46, p = 0.0403, p(c) > 0.05). By subgroup analysis, the MICA*A4 allele significantly increased in seropositive RA patients versus controls (23.0% vs. 14.8%, OR = 1.69, p = 0.0082, p(c) = 0.041). HLA-DRB1*0405 was strongly associated with RA (p(c) = 0.0000008), and strong linkage disequilibrium was observed between HLA-DRB1*0405 and MICA*A4 alleles in controls (p(c) = 0.000004) as well as in RA patients (p(c) = 0.0012). In Korean patients, HLA-DRB1*0405 was primarily associated with RA and the weak association of RA with MICA*A4 was secondary to that with HLA-DRB1*0405. Additionally, MICA*A9 might have a weak protective effect on the susceptibility to RA in Koreans.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Artrite Reumatoide
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Antígenos de Histocompatibilidade Classe I
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Repetições de Microssatélites
Tipo de estudo:
Risk_factors_studies
Limite:
Adolescent
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Adult
/
Aged
/
Child
/
Humans
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Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Hum Immunol
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Coréia do Sul