The role of glutathione in renal cortical tissue. Effects of diamide on Na+ and GSSG levels, amino acid transport and Na+-K+-ATPase activity.
Mol Cell Biochem
; 18(2-3): 109-15, 1977 Dec 29.
Article
em En
| MEDLINE
| ID: mdl-146823
ABSTRACT
The effects of diamide were studied in rat kidney cortical tissue. It was found that diamide increased oxidized glutathione levels and inhibited Na+-K+-ATPase activity. Consistent with this finding was the observation that diamide compromised the sodium gradients maintained in renal cortical slices. Amino acid transport studies with ouabain or a sodium-free buffer indicated that diamide interferes with both Na+-dependent and Na+-independent transport systems. These results indicate that diamide has a number of different effects on renal cortical tissue and emphasize the important role of glutathione in maintaining control of a number of key metabolic pathways.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sódio
/
Compostos Azo
/
Adenosina Trifosfatases
/
Diamida
/
Aminoácidos
/
Glutationa
/
Córtex Renal
Limite:
Animals
Idioma:
En
Revista:
Mol Cell Biochem
Ano de publicação:
1977
Tipo de documento:
Article