Structure-based design of carboxybiphenylindole inhibitors of the ZipA-FtsZ interaction.
Org Biomol Chem
; 1(23): 4138-40, 2003 Dec 07.
Article
em En
| MEDLINE
| ID: mdl-14685315
ABSTRACT
Structural features of two weak inhibitors of the ZipA-FtsZ protein-protein interaction which were found to bind to overlapping but different areas of the key binding site were combined in one new series of carboxybiphenyl-indoles with improved inhibitory activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
/
Desenho de Fármacos
/
Proteínas de Transporte
/
Proteínas de Ciclo Celular
/
Proteínas de Escherichia coli
/
Proteínas do Citoesqueleto
/
Indóis
Idioma:
En
Revista:
Org Biomol Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Estados Unidos