Inhibition of the vascular-endothelial growth factor-induced intracellular signaling and mitogenesis of human endothelial cells by epigallocatechin-3 gallate.
Eur J Pharmacol
; 483(2-3): 223-7, 2004 Jan 12.
Article
em En
| MEDLINE
| ID: mdl-14729110
ABSTRACT
Galloyl group-containing catechins, such as epigallocatechin-3 gallate, inhibit receptor tyrosine kinase activity of several growth factor receptors. This study investigated the effects of epigallocatechin-3 gallate, as compared to epicatechin, on vascular endothelial growth factor-induced intracellular signaling and mitogenesis of human umbilical endothelial cells. Epigallocatechin-3 gallate concentration-dependently inhibited vascular endothelial growth factor-induced DNA synthesis, cell proliferation, autophosphorylation of vascular endothelial growth factor receptors-1 and -2, phosphorylation of extracellular signal-regulated kinases-1 and -2, and mRNA expression of the early growth response factor-1. In contrast, epicatechin was not effective. Thus, epigallocatechin-3 gallate may be an attractive candidate drug to inhibit tumour angiogenesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistemas do Segundo Mensageiro
/
Catequina
/
Células Endoteliais
/
Fator A de Crescimento do Endotélio Vascular
/
Mitógenos
Limite:
Humans
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Alemanha