[Analysis of DNA ploidy in 3,050 cases of malignant tumors].

ABSTRACT

DNA ploidy in paraffin-embedded sections collected from 3,050 cases of malignant tumors was analysed by flow cytometry. The result showed that DNA index distribution was ranged from 0.6 to 2.6, mostly at 1.10 to 1.85. DNA ploidy distribution showed that 536 cases (17.6%) were DNA diploid tumors; 2,227 cases (73.0%) were tumors with DNA aneuploid; 126 cases (4.1%) accompanied with tetraploid; and 161 cases (5.3%) with multiploid. Additionally, relationship between the histologic type as well as the grading and DNA ploid were also analysed in 1,117 cases of malignant tumors. The results indicated that DNA index was not correlated with the histologic typing, but correlated with the histologic grading (grade I DI = 1.24, grade II DI = 1.38, grade III DI = 1.51). It's considered that flow cytometry DNA grade index may be an objective and precise quantitative marker in judging the degree, grade and differentiation of tumor malignancy.