[Associations of Bsm1 polymorphism of the vitamin D receptor gene and blood lead, zinc protoporphyrin, and physical development in 476 environmental lead-exposed children].
Wei Sheng Yan Jiu
; 32(6): 610-2, 2003 Nov.
Article
em Zh
| MEDLINE
| ID: mdl-14963917
ABSTRACT
The associations of the Bsm1 polymorphism of vitamin D receptor gene and blood lead, zinc protoporphyrin and physical development in 476 environmental lead-exposed children were studied. After blood lead level, age, sex and education level of the patients were adjusted by analysis of covariance, the children with B allele had larger head circumference than those with bb genotype(P = 0.02). While the subjects were stratified by blood lead level and sex, the statistically significant difference in head circumference between different Bsm1 genotypes was found only in high-blood-lead subgroup and in male subgroup. No significant influence of Bsm1 polymorphism on blood lead level, zinc protoporphyrin, height and weight was found, suggesting that the Bsm1 polymorphism of VDR gene may modify the effect of lead on the skull development of children highly exposed to lead.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Protoporfirinas
/
Desenvolvimento Infantil
/
Receptores de Calcitriol
/
Exposição Ambiental
/
Chumbo
Tipo de estudo:
Risk_factors_studies
Limite:
Child
/
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Wei Sheng Yan Jiu
Assunto da revista:
SAUDE PUBLICA
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
China