Improved photostability and fluorescence properties through polyfluorination of a cyanine dye.
Org Lett
; 6(6): 909-12, 2004 Mar 18.
Article
em En
| MEDLINE
| ID: mdl-15012062
ABSTRACT
[structure see text] A polyfluorinated cyanine dye has been synthesized and characterized. Compared with the nonfluorinated analogue, the dye exhibits significantly reduced aggregation in aqueous media, enhanced fluorescence quantum yield, greater resistance to photobleaching upon direct irradiation, and reduced reactivity toward singlet oxygen. All of these properties are favorable for use of cyanine dyes as fluorescent labels and point toward fluorination as a general strategy for improving performance in imaging applications.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carbocianinas
/
Corantes Fluorescentes
/
Flúor
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos