Oxygen free radical scavenger enzyme polymorphisms in systemic sclerosis.
Free Radic Biol Med
; 36(11): 1403-7, 2004 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-15135176
ABSTRACT
We performed a case-control study of polymorphisms of glutathione S-transferase (GST) isoenzymes and manganese superoxide dismutase (MnSOD) in black South Africans with systemic sclerosis (SSc). The frequency of the GSTM1*B phenotype was significantly decreased in the overall SSc group compared with controls (OR=0.19, p(corr)<.05), implying a possible protective effect against development of the disease. There was also a trend toward increased MnSODAla allele and phenotype frequencies in the diffuse cutaneous SSc subset compared with controls (OR=2.11 and 3.15, respectively, p(corr)<.1). Our findings provide new data on the distribution of GST and MnSOD polymorphisms in healthy Africans and further evidence that genetic factors may have a contributory role to play in predisposing to oxidative stress in SSc.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Polimorfismo Genético
/
Escleroderma Sistêmico
/
Superóxido Dismutase
/
Sequestradores de Radicais Livres
/
Glutationa Transferase
Tipo de estudo:
Observational_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Free Radic Biol Med
Assunto da revista:
BIOQUIMICA
/
MEDICINA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
África do Sul