Involvement of substance P in scratching behaviour in an atopic dermatitis model.
Eur J Pharmacol
; 491(2-3): 191-4, 2004 May 03.
Article
em En
| MEDLINE
| ID: mdl-15140636
ABSTRACT
Substance P is speculated to be a key mediator of itching in atopic dermatitis, possibly acting via the tachykinin NK1 receptor. Thus, we examined the effect of a tachykinin NK1 antagonist, BIIF 1149 CL, on scratching behaviour in a picrylchloride-induced dermatitis model in NC/Nga mice. BIIF 1149 CL ((S)-N-[2-[3,5-bis(trifluoromethyl) phenyl]ethyl]-4-(cyclopropylmethyl)-N-methyl-alpha-phenyl-1-piperazineacetamide, monohydrochloride, monohydrate) at a dose of 100 mg/kg, p.o., significantly inhibited scratching behaviour immediately after administration, and the effect continued up to 6 h. The results suggest that clinical trials of tachykinin NK1 antagonists for the treatment of itching in atopic dermatitis patients would be warranted.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Prurido
/
Comportamento Animal
/
Substância P
/
Dermatite Atópica
/
Modelos Animais de Doenças
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Japão