Staphylococcal methicillin resistance: fine focus on folds and functions.
FEMS Microbiol Lett
; 235(1): 1-8, 2004 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-15158255
ABSTRACT
Globalisation has entailed a massive increase in trade and human mobility facilitating the rapid spread of infectious agents, including those that are drug resistant. A particularly serious threat to human health is posed by methicillin-resistant staphylococcal strains which have acquired molecular mechanisms to evade the action of beta-lactam antibiotics (BLAs). Full expression of high-level methicillin resistance involves a complex network of molecules and depends primarily on sufficient expression of a penicillin-binding protein with low sensitivity towards BLAs. Other factors include the fine-tuned regulation of autolytic activity of cell-wall components, as well as an optimal rate of peptidoglycan precursor formation and a highly specific peptidoglycan precursor structure. Three-dimensional structural data are available on several of the pieces involved in the jigsaw puzzle and provide a molecular basis for the understanding of methicillin resistance and for the design of new therapeutic strategies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Staphylococcus
/
Proteínas de Bactérias
/
Resistência a Meticilina
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
FEMS Microbiol Lett
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Espanha