[Alterations in myocardial function in early stage of sepsis in rabbits].
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
; 16(6): 355-7, 2004 Jun.
Article
em Zh
| MEDLINE
| ID: mdl-15182449
ABSTRACT
OBJECTIVE:
To study the alterations in myocardial function in early stage of sepsis.METHODS:
Twenty rabbits were randomly divided into two groups. In the control group (n=10) only laparotomy was done, and in the sepsis group the animals received cecal ligation and puncture (CLP). In both groups left ventricular catheter was placed via right internal carotid artery. Left ventricular systolic peak pressure (LVSP), maximal positive change in filling pressure versus time (+dp/dt max), maximal negative change in filling pressure versus time (-dp/dt max) were monitored, and serum troponin I (TnI) was measured per hour for five times (0, 1, 2, 3, 4 hours after operation).RESULTS:
Compared to the basic levels, LVSP, +dp/dt max and -dp/dt max decreased significantly an hour after CLP in sepsis group (all P<0.05), with the tendency of decrease with elapse of time. Serum TnI increased significantly an hour after CLP in sepsis group, and continued to increase with the passage of time. In contrast, no significant change was observed in control group.CONCLUSION:
Cardiac muscle is injured, and myocardial systolic and diastolic functions are depressed in early stage of sepsis in rabbit model.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sepse
/
Troponina I
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue
Assunto da revista:
MEDICINA DE EMERGENCIA
/
TERAPIA INTENSIVA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
China