Communications blackout? Do N-acylhomoserine-lactone-degrading enzymes have any role in quorum sensing?
Microbiology (Reading)
; 150(Pt 7): 2023-2028, 2004 Jul.
Article
em En
| MEDLINE
| ID: mdl-15256546
ABSTRACT
A number of bacteria, including some significant pathogens, utilize N-acylhomoserine lactones (AHLs) as quorum sensing signals. There is considerable interest in the therapeutic potential of disrupting quorum sensing. Recently, a number of bacteria have been identified which are capable of enzymic inactivation of AHLs. These enzymes show considerable promise as 'quenchers' of quorum sensing. However, the assumption that the natural function of these enzymes is to disrupt or modulate quorum sensing has yet to be established. This review surveys the progress made to date in this field and examines what implications these findings have for our understanding of the role played by these enzymes in vivo.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bactérias
/
4-Butirolactona
/
Hidrolases de Éster Carboxílico
/
Regulação Bacteriana da Expressão Gênica
/
Amidoidrolases
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Microbiology (Reading)
Assunto da revista:
MICROBIOLOGIA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Reino Unido