Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs.
Nat Neurosci
; 7(11): 1184-6, 2004 Nov.
Article
em En
| MEDLINE
| ID: mdl-15475951
ABSTRACT
Distinct classes of GABAergic synapses target restricted subcellular domains, thereby differentially regulating the input, integration and output of principal neurons, but the underlying mechanism for such synapse segregation is unclear. Here we show that the distributions of two major classes of GABAergic synapses along the perisomatic and dendritic domains of pyramidal neurons were indistinguishable between primary visual cortex in vivo and cortical organotypic cultures. Therefore, subcellular synapse targeting is independent of thalamic input and probably involves molecular labels and experience-independent forms of activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sinapses
/
Tálamo
/
Córtex Visual
/
Células Piramidais
/
Extensões da Superfície Celular
/
Ácido gama-Aminobutírico
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Nat Neurosci
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos