Evidence of altered T-lymphocyte number and proliferative responses in genetically epilepsy-prone rats.
J Neuroimmunol
; 37(1-2): 93-7, 1992 Mar.
Article
em En
| MEDLINE
| ID: mdl-1548378
ABSTRACT
Genetically epilepsy-prone (GEPR-9) rats exhibit decreased antibody plaque-forming cell responses following immunization. We examined the hypothesis that this immunosuppression was due to deficits in the number or proliferative responses of T-lymphocytes. Splenocyte responses to concanavalin A and pokeweed mitogen were significantly greater in GEPR-9 rats than controls. Flow cytometric analysis indicated that GEPR-9 rats possess an increase in T-cells associated with the T-helper phenotype. The increased proportion of T-helper cells in GEPR-9 rats may underlie their enhanced proliferative responses to T-cell mitogens. These results clearly indicate that the failure of the GEPR-9 rat to respond to a T-dependent antigen in vivo is not due to a lack of T-helper activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Epilepsia
Limite:
Animals
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
1992
Tipo de documento:
Article