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Expression of interleukin-17B in mouse embryonic limb buds and regulation by BMP-7 and bFGF.
You, Zongbing; DuRaine, Grayson; Tien, Janet Y L; Lee, Corinne; Moseley, Timothy A; Reddi, A Hari.
Afiliação
  • You Z; Department of Orthopaedic Surgery, Center for Tissue Regeneration and Repair, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA. zyou@ucdavis.edu
Biochem Biophys Res Commun ; 326(3): 624-31, 2005 Jan 21.
Article em En | MEDLINE | ID: mdl-15596145
ABSTRACT
Interleukin-17B (IL-17B) is a member of interleukin-17 family that displays a variety of proinflammatory and immune modulatory activities. In this study, we found that IL-17B mRNA was maximally expressed in the limb buds of 14.5 days post coitus (dpc) mouse embryo and declined to low level at 19.5 dpc. By immunohistochemical staining, the strongest IL-17B signals were observed in the cells of the bone collar in the primary ossification center. The chondrocytes in the resting and proliferative zones were stained moderately, while little staining was seen in the hypertrophic zone. Furthermore, in both C3H10T1/2 and MC3T3-E1 cells, the IL-17B mRNA was up-regulated by recombinant human bone morphogenetic protein-7, but down-regulated by basic fibroblast growth factor via the extracellular signal-regulated kinase pathway. This study provides the first evidence that IL-17B is expressed in the mouse embryonic limb buds and may play a role in chondrogenesis and osteogenesis.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator 2 de Crescimento de Fibroblastos / Fator de Crescimento Transformador beta / Proteínas Morfogenéticas Ósseas / Interleucina-17 / Embrião de Mamíferos Limite: Animals Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2005 Tipo de documento: Article País de afiliação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator 2 de Crescimento de Fibroblastos / Fator de Crescimento Transformador beta / Proteínas Morfogenéticas Ósseas / Interleucina-17 / Embrião de Mamíferos Limite: Animals Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2005 Tipo de documento: Article País de afiliação: Estados Unidos