Engineered single chain antibody fragments for radioimmunotherapy.
Q J Nucl Med Mol Imaging
; 48(4): 279-88, 2004 Dec.
Article
em En
| MEDLINE
| ID: mdl-15640791
ABSTRACT
An ideal molecule to deliver radioimmunotherapy (RIT) would be target specific and have prolonged residence time at high concentrations in the tumour with rapid clearance from normal tissues. It would also be non-immunogenic. These features can be rationally introduced into recombinant antibody-based proteins using antibody engineering techniques. This review focuses on the use of antibody engineering in the design and development of RIT molecules which have single chain Fv (scFv) antibody fragments as building blocks.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Imunoglobulinas
/
Desenho de Fármacos
/
Engenharia de Proteínas
/
Radioimunoterapia
/
Anticorpos Monoclonais
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Q J Nucl Med Mol Imaging
Assunto da revista:
MEDICINA NUCLEAR
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Reino Unido