S100A1 and KIT gene expressions in common subtypes of renal tumours.
Eur J Surg Oncol
; 31(3): 299-303, 2005 Apr.
Article
em En
| MEDLINE
| ID: mdl-15780567
ABSTRACT
AIM:
The aim of this study is to evaluate the S100A1 and KIT as gene markers for the differentiation of common subtypes of renal tumours.METHODS:
Fifty-five tissue samples (15 clear cell RCCs, 15 papillary RCCs, 7 chromophobe RCCs, 8 oncocytomas and 10 normal renal tissues) were studied The gene expressions of S100A1 and KIT were analysed by one-step RT-PCR by using the specific primers.RESULTS:
S100A1 was expressed in 2/15 clear cell RCCs, 11/15 papillary RCCs, 7/8 oncocytomas and in 0/7 chromophobe RCCs. KIT gene was expressed in 6/7 chromophobe RCCs and 7/8 oncocytomas while 0/15 clear cell RCCs and 1/15 papillary RCCs expressed kit gene. Normal tissue expressed neither S100A1 nor KIT gene.CONCLUSION:
S100A1 and KIT can be used as gene markers for the differentiation of common subtypes of renal tumours.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas S100
/
Biomarcadores Tumorais
/
Regulação Neoplásica da Expressão Gênica
/
Proteínas Proto-Oncogênicas c-kit
/
Neoplasias Renais
Limite:
Humans
Idioma:
En
Revista:
Eur J Surg Oncol
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
França