Synthesis of a C20-C26 segment of superstolide A by addition of a chiral allenylzinc reagent to (R)-N-boc alaninal.
Org Lett
; 7(8): 1593-6, 2005 Apr 14.
Article
em En
| MEDLINE
| ID: mdl-15816760
ABSTRACT
[reaction see text] Additions of chiral allenylzinc and indium reagents to N-Boc alaninal were examined as a possible route to a C20-C26 segment of superstolide A. Allenylzinc reagents, prepared in situ by palladiozincation of (R)- and (S)-5-pivalyloxy-3-butyn-2-ol mesylate, showed excellent reagent control to afford the anti,syn and anti,anti diastereomers as the nearly exclusive adducts.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piranos
/
Tetra-Hidronaftalenos
/
Macrolídeos
/
Alanina
Limite:
Animals
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos