Analysis of KL-6 and SP-D as disease markers in bird fancier's lung.
Sarcoidosis Vasc Diffuse Lung Dis
; 22(1): 51-7, 2005 Mar.
Article
em En
| MEDLINE
| ID: mdl-15881280
ABSTRACT
BACKGROUND AND AIM:
KL-6 and SP-D are potential serum markers in interstitial lung diseases. Their discriminative value, and ability to reflect pulmonary disease activity and prognosis in bird fancier's lung were analyzed.METHODS:
We studied 49 patients, 38 unexposed and 9 exposed controls. Serum KL-6 and SP-D concentrations were measured at presentation and a second sample, taken after antigen avoidance, was available in 17 patients. Pulmonary function tests were analyzed at presentation and 2-year follow-up.RESULTS:
KL-6 and SP-D were significantly elevated in patients compared to controls (p < 0.0001). ROC curve analysis revealed that both are equally useful in discriminating patients from controls. Analysis of their value as activity markers showed that both correlated with pulmonary function impairment; however, KL-6 correlated best with diffusing capacity. Evaluation of their predictive value showed that higher levels at onset were associated with improvement of diffusing capacity during follow-up. Further, it was noted that KL-6 and SP-D levels decreased after more than one month of allergen avoidance.CONCLUSIONS:
KL-6 and SP-D appear useful serum markers in bird fancier's lung. Since higher levels are associated with more severe lung function impairment at presentation, and better recovery over time, we postulate that in this disease they are especially markers of disease activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pulmão do Criador de Aves
/
Glicoproteínas
/
Proteína D Associada a Surfactante Pulmonar
/
Antígenos
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Sarcoidosis Vasc Diffuse Lung Dis
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
ANGIOLOGIA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Holanda