[Isolation and identification of a gene: attractin related to inhibiting erythroid differentiation in K562 cells].
Yi Chuan
; 24(1): 1-5, 2002 Jan.
Article
em Zh
| MEDLINE
| ID: mdl-15901552
ABSTRACT
Differential display PCR method was used to isolate four differential display fragments between the wild type K562 cell line and the variant type K562 cell line that expressed the human beta-globin gene. After sequencing, the most remarkable different fragment,named dd1,was selected for further study. The analysis of RT-PCR and Northern blot hybridization showed that dd1 was exactly the differentiation fragment between the two cell lines. The homology analysis indicated that dd1 was matched to Attractin (GeneBank registration No.AF106861). It might be an adhesion receptor related to inhibiting erythroid differentiation based on its structure.
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01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
Idioma:
Zh
Revista:
Yi Chuan
Assunto da revista:
GENETICA
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
China