On the optimisation of the bed porosity and the particle shape of ordered chromatographic separation media.
J Chromatogr A
; 1073(1-2): 43-51, 2005 May 06.
Article
em En
| MEDLINE
| ID: mdl-15909504
ABSTRACT
We report on a theoretical study wherein we considered a large number of ordered two-dimensional porous pillar arrays with different pillar shapes and widely varying external porosity and calculated the flow resistance and the band broadening (under retentive conditions) over the complete range of practical velocities using a commercial computational fluid dynamics software package. It is found that the performance of the small porosity systems is very sensitive to the exact pillar shape, whereas this difference gradually disappears with increasing porosity. The obtained separation impedances are very small in comparison to packed bed and monolithic columns and decrease with increasing porosity. If accounting for the current micromachining limitations, a proper selection of the exact shape and porosity even becomes more critical, and different design rules are obtained depending on whether porous or non-porous pillars are considered.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromatografia Líquida
Idioma:
En
Revista:
J Chromatogr A
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Bélgica