[Early impairment of renal function in chronic heart failure and its clinical significance].

ABSTRACT

OBJECTIVE: To observe the changes of the microproteinuria (MA) and the relationship in patients with chronic heart failure (CHF). METHODS: Routine urine protein, blood creatinine and urea nitrogen and MA, immunoglobulin G (UIgG), retinal-binding protein (URbp) and beta-2-microglobulin (Ubeta(2)-MG) were measured and analyzed in 25 patients with CHF, 22 patients with cardiovascular diseases but compensated heart function s and 20 normal volunteers. RESULTS: The levels of Ualb and UIgG in the CHF group were significantly higher than those in the normal group and compensated heart function group [(7.49 +/- 10.47) mg/mmolCr vs (1.19 +/- 0.85) mg/mmolCr and (1.63 +/- 1.62) mg/mmolCr; (0.82 +/- 1.47) mg/mmolCr vs (0.27 +/- 0.15) mg/mmolCr and (0.40 +/- 0.49) mg/mmolCr; P < 0.01; P < 0.05; respectively] and they were negatively correlated with left ventricular ejection fraction (r = -0.31, r = -0.40, P < 0.01). There were no significant difference of URbp and Ubeta(2)-MG among the above three groups. CONCLUSIONS: There is early abnormality of renal function in CHF patients without primary renal disorder and the abnormality was featured by impaired glomerular filtration function. The more severe the heart failure, the more significant the renal function impairment.