A 10-day levofloxacin-based triple therapy in patients who have failed two eradication courses.
Aliment Pharmacol Ther
; 22(1): 45-9, 2005 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-15963079
ABSTRACT
BACKGROUND:
A standard third-line treatment is lacking, and European guidelines recommend performing culture in these patients. However, the use of this procedure as 'routine practice' is definitively not feasible.AIM:
To evaluate the eradication rate of a 10-day levofloxacin-based triple therapy in patients who have failed two eradication courses for Helicobacter pylori.METHODS:
A total of 151 patients with persistent Helicobacter pylori infection after two treatments were studied. Patients were considered positive if two of three endoscopic tests were positive. Susceptibility testing was also performed. Patients received a standard dose of proton-pump inhibitors twice daily, levofloxacin 250 mg twice daily and amoxicillin 1 g twice daily, for 10 days. Endoscopic follow-up was carried out 4-6 weeks after the end of eradication therapy.RESULTS:
About 76% (95% CI 68.8-82.3), and 85% (95% CI 77.5-89.7) of patients were eradicated according to intention-to-treat and per-protocol analysis, respectively. Eradication rates of the strains showed as 92% (95% CI 83.2-96.7) of those resistant to both metronidazole and clarithromycin but susceptible to levofloxacin.CONCLUSIONS:
In patients who failed previous regimens, the 10-day levofloxacin-based triple therapy is safe and effective, allowing eradication in almost 80% of the patients.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ofloxacino
/
Helicobacter pylori
/
Infecções por Helicobacter
/
Levofloxacino
/
Antibacterianos
Tipo de estudo:
Guideline
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Aliment Pharmacol Ther
Assunto da revista:
FARMACOLOGIA
/
GASTROENTEROLOGIA
/
TERAPIA POR MEDICAMENTOS
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Itália