Composition-controlled nanocomposites of apatite and collagen incorporating silicon as an osseopromotive agent.
J Biomed Mater Res A
; 74(3): 447-53, 2005 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-15983990
ABSTRACT
The development of a novel biocomposite of apatite (Ap) and collagen incorporating low-level additions of silicon (Si) as an osseopromotive agent is detailed. Designed to mimic the structural and compositional characteristics of developing bone, this composite is produced via a coprecipitation method, through which the weight percentage of Ap (i.e., the Ap/collagen ratio) can be varied. Coprecipitates produced at Ap contents of 80 wt % (Ap/collagen=41), 60 wt % (Ap/collagen=32), and 40 wt % (Ap/collagen=23) Ap showed markedly different morphologies, ranging from ceramic-like particulates to rope-like macro-fibrils; at all three Ap contents, however, the nanostructural features of the composites remained qualitatively indistinguishable, with equiaxed Ap nanocrystals distributed randomly throughout a matrix of amorphous collagen. Si incorporation was observed to occur preferentially in the collagenous phase-a result with potential impact on local controlled release of Si.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Silício
/
Colágeno
/
Substitutos Ósseos
/
Nanoestruturas
/
Hidroxiapatitas
Limite:
Animals
Idioma:
En
Revista:
J Biomed Mater Res A
Assunto da revista:
ENGENHARIA BIOMEDICA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Reino Unido