[Urinary concentration of proinflammatory cytokines with regard to infected urinary tract region]. / Stezenie cytokin prozapalnych w moczu w zaleznosci od umiejscowienia zakazenia w drogach moczowych.
Wiad Lek
; 58 Suppl 1: 14-9, 2005.
Article
em Pl
| MEDLINE
| ID: mdl-16060078
ABSTRACT
UNLABELLED Uropathogenic bacteria stimulate epithelial cells of interstitial tissue and macrophages to secrete proinflammatory cytokines interleukin I (IL-1beta), interleukin 6 (IL-6) and interleukin 8 (IL-8). The aim of the study was to check 1) if the concentration of proinflammatory cytokines (IL-1beta, IL-6, IL-8) differs in dependence on region and clinical picture of urinary tract infection, 2) what is the influence of antibacterial treatment on their concentration. MATERIAL:
We examined 67 children, aged 1-15 years, who were divided into 3 groups 27 children with acute pyelonephritis (AP), caused by E. coli (group I), in whom the examination was carried out twice A - before treatment, B - after 14 days of antibacterial treatment, 10 children with chronic urinary tract infection (UTI) associated with neurogenic bladder (group II) and 30 healthy children (group K).METHOD:
Urinary concentration of examined cytokines was assessed using ELISA immunoenzymatic method and was expressed in pg/mg creatinine. Results showed that in group I before treatment the urinary concentration of examined cytokines was increased (p<0.05). After antibacterial treatment concentration of IL-1beta was normal and concentration of IL-6 and IL-8 decreased but was still higher than in control group (p<0.05). In group II before treatment the increase in concentration of IL-1beta and IL-8 was not so high (p<0.05) and the urinary concentration of IL-6 was normal (p>0.05). In examination A in children from group I and II a positive correlation between examined cytokines and C reactive protein was shown. We have also found a positive correlation between urinary concentration of IL-1beta a IL-8.CONCLUSIONS:
1. Urinary concentration of examined proinflammatory cytokines is different in children with AP and UTI associated with neurogenic bladder and correlates with concentration of C-reactive protein. 2. In most of children with AP after 14-days of antibacterial treatment the urinary concentration of proinflammatory cytokines has been increased.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pielonefrite
/
Infecções Urinárias
/
Bexiga Urinaria Neurogênica
/
Citocinas
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
País/Região como assunto:
Europa
Idioma:
Pl
Revista:
Wiad Lek
Assunto da revista:
MEDICINA
Ano de publicação:
2005
Tipo de documento:
Article