Expression and translation of the growth hormone-receptor gene in the guinea-pig.
J Endocrinol
; 133(3): 357-62, 1992 Jun.
Article
em En
| MEDLINE
| ID: mdl-1613436
ABSTRACT
The refractoriness of guinea-pigs to the growth-promoting actions of exogenous GH has been suggested to be due to a deficiency or defect in tissue GH receptors or in GH-receptor gene expression. GH-receptor mRNA was, however, demonstrated by Northern blot analysis and by the polymerase chain reaction in extracts of guinea-pig liver, adipose tissue, brain, hypothalamus and pituitary gland. High-affinity, low-capacity binding sites for radio-labelled ovine GH were also demonstrated on the plasma membranes of guinea-pig liver and were similar to those in rat liver. These results demonstrate that the unresponsiveness of guinea-pigs to exogenous GH is not due to the absence of GH receptors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biossíntese de Proteínas
/
Receptores da Somatotropina
/
Expressão Gênica
Limite:
Animals
Idioma:
En
Revista:
J Endocrinol
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Canadá