von Willebrand factor antigen in hypertrophic osteoarthropathy.
J Rheumatol
; 19(5): 765-7, 1992 May.
Article
em En
| MEDLINE
| ID: mdl-1613707
ABSTRACT
Recent evidence suggests that a key feature in the pathogenesis of hypertrophic osteoarthropathy (HOA) is an enhanced local platelet vessel wall interaction in the affected extremities. In our investigation we measured plasma levels of von Willebrand Factor Antigen (vWFAg; ELISA assay), a marker of platelet and/or endothelial activation, in 5 patients with the primary form of HOA and in 6 patients with the secondary form (due to cyanotic heart disease). Seven subjects matched for sex and age were used as controls. Patients showed statistically significantly higher levels of vWFAg in the primary (163.8 +/- 13.9%) and secondary form (152.6 +/- 9.6%, p less than 0.001 for both) when compared to controls (100.4 +/- 6.3%). Our results support the notion that platelet endothelial cell interaction may play a key role in the development of HOA.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoartropatia Hipertrófica Primária
/
Antígenos
Tipo de estudo:
Etiology_studies
Limite:
Adolescent
/
Adult
/
Child
/
Humans
/
Male
Idioma:
En
Revista:
J Rheumatol
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Itália