[Prevention of Rhodiola-astragalus membranaceus compounds against simulated plateau hypoxia brain injury in rat].
Space Med Med Eng (Beijing)
; 18(4): 303-5, 2005 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-16224855
ABSTRACT
OBJECTIVE:
To observe the protective effects of Rhodiola-astragalus membranaceus mixture against brain damage during hypoxia under simulated plateau environment and the mechanisms maybe involved in.METHOD:
Adult SD rats were randomly divided into 3 groups, which were normoxic control, simulated plateau hypoxia, and Rhodiola-astragalus membranaceus mixture pretreatment group. Rats in the latter two groups were exposed to simulated 8000 m altitude in a hypobaric chamber for 7 h. Water content, Na+, K(+)-ATPase activity and SOD activity in cerebral tissue, malondialdehyde (MDA) and lactic acid content in cerebral homogenate and serum were measured.RESULT:
As compared with control group, cerebral water content was significantly higher in hypoxia group, while it was obviously lower in pretreatment group. MDA contents of hypoxia group both in cerebral homogenate and serum were higher than that of control group, while the pretreatment group they were both decreased obviously. Lactic acid content of hypoxia group in cerebral and in serum increased markedly and decreased drastically in pretreatment group compared to that of hypoxic group.CONCLUSION:
Rhodiola-astragalus membranaceus mixture has preventive effects on hypoxic damage induced by simulated plateau environment. This prevention may be related to the antagonistic effect on membrane lipid peroxidation and the inhibition on the accumulation of lactic acid in brain tissue and serum.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medicamentos de Ervas Chinesas
/
Hipóxia Encefálica
/
Astragalus propinquus
/
Rhodiola
/
Altitude
Limite:
Animals
Idioma:
Zh
Revista:
Space Med Med Eng (Beijing)
Assunto da revista:
ENGENHARIA BIOMEDICA
/
MEDICINA AEROESPACIAL
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
China