Synthesis and activity of an octapeptide inhibitor designed for SARS coronavirus main proteinase.
Peptides
; 27(4): 622-5, 2006 Apr.
Article
em En
| MEDLINE
| ID: mdl-16242214
ABSTRACT
The outbreak of SARS, a life-threatening disease, has spread over many countries around the world. So far there is no effective drug for the treatment of SARS. Stimulated by the binding mechanism of SARS-CoV Mpro with the octapeptide AVLQSGFR reported recently as well as the "Chou's distorted key" theory, we synthesized the octapeptide AVLQSGFR for conducting various biochemical experiments to investigate the antiviral potential of the octapeptide against SARS coronavirus (BJ-01). The results demonstrate that, compared with other compounds reported so far, AVLQSGFR is the most active in inhibiting replication of the SARS coronavirus, and that no detectable toxicity is observed on Vero cells under the condition of experimental concentration.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Oligopeptídeos
/
Proteínas Virais
/
Coronavírus Relacionado à Síndrome Respiratória Aguda Grave
/
Inibidores Enzimáticos
Limite:
Animals
Idioma:
En
Revista:
Peptides
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
China