[Analysis of secreted proteases of Trichophyton rubrum].
Wei Sheng Wu Xue Bao
; 45(4): 601-5, 2005 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-16245880
ABSTRACT
Secreted proteases are thought as potential virulent factors of Tricophyton rubrum. Based on cDNA libraries of 6 physiological phases of Tricophyton rubrum, 9683 unique ESTs were obtained by DNA sequencing. By bioinformatic analysis, 18 ESTs of putative secreted proteases were obtained from the established ESTs library, including 4 secreted peptidases, 1 secreted metalloprotease, 2 extracellular serine proteases, 1 secreted aspartic proteinase, 9 secreted subtilisin-like proteases and 1 vacuolar serine protease. These secreted proteases are related to nutrient uptake, lesion extension and host immune responses elicitation in the process of T. rubrum infection. These results provide a clue to further research on the infection and pathogencity of T. rubrum.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeo Hidrolases
/
Trichophyton
Tipo de estudo:
Prognostic_studies
Idioma:
Zh
Revista:
Wei Sheng Wu Xue Bao
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
China