The synthesis and preliminary biological evaluation of a novel steroid with neurotrophic activity: NGA0187.
J Org Chem
; 70(24): 9849-56, 2005 Nov 25.
Article
em En
| MEDLINE
| ID: mdl-16292815
ABSTRACT
[structure, reaction see text] A full account of the total synthesis of neurotrophic compound NGA0187 is provided. A key feature of the synthesis involved the direct selective oxidation of 6alpha,7beta-diol to install the unusual 6,7-ketol moiety and stereoselective conjugate addition of vinyl cuprate to enone. A preliminary evaluation of its ability to stimulate the neurite outgrowth was also evaluated with PC12 cell.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triterpenos
/
Neurônios
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos