Hedgehog and spinal cord injury.
Expert Opin Ther Targets
; 9(6): 1137-45, 2005 Dec.
Article
em En
| MEDLINE
| ID: mdl-16300466
ABSTRACT
The hedgehog (Hh) pathway is a highly conserved signalling cascade involved in many developmental processes, including a key role in morphogenesis of many tissues including the limb bud, lung, gut, hair follicle and the neural tube. Hh role in adult tissue is less well-established, however, it is known that the pathway becomes activated and reutilised in situations of repair and regeneration. In the nervous system, tissue repair appears impeded in that mature neurons undergo their final cell divisions early in life and central axons do not easily regenerate. The Hh pathway has been shown to be activated in response to nerve damage, leading to the hypothesis that enhancing Hh pathway activation in damaged nerve tissue, inducing the repair process, could offer a potentially new approach to treating neurodegenerative diseases and dysfunction, including spinal cord injury.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Traumatismos da Medula Espinal
/
Transdução de Sinais
/
Transativadores
/
Proteínas de Drosophila
/
Regeneração Nervosa
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Expert Opin Ther Targets
Assunto da revista:
TERAPEUTICA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos