Clonidine treatment for agitation in children after sevoflurane anesthesia.
Anesth Analg
; 101(6): 1619-1622, 2005 Dec.
Article
em En
| MEDLINE
| ID: mdl-16301230
Clonidine is effective in treating sevoflurane-induced postanesthesia agitation in children. We conducted a study on 169 children to quantify the risk reduction of clonidine agitation in patients admitted to our day-surgery pediatric clinic. Children were randomly allocated to receive clonidine 2 mug/kg or placebo before general anesthesia with sevoflurane that was also supplemented with a regional or central block. An observer blinded to the anesthetic technique assessed recovery variables and the presence of agitation. Pain and discomfort scores were significantly decreased in the clonidine group; the incidence of agitation was reduced by 57% (P = 0.029) and the incidence of severe agitation by 67% (P = 0.064). Relative risks for developing agitation and severe agitation were 0.43 (95% confidence interval, 0.24-0.78) and 0.32 (0.09-1.17), respectively. Clonidine produces a substantial reduction in the risk of postsevoflurane agitation in children.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Agitação Psicomotora
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Clonidina
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Agonistas alfa-Adrenérgicos
/
Anestésicos Inalatórios
/
Éteres Metílicos
Tipo de estudo:
Clinical_trials
/
Etiology_studies
Limite:
Child
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Child, preschool
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Humans
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Infant
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Newborn
Idioma:
En
Revista:
Anesth Analg
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Itália