Isolation and sequence of a cDNA coding for the immunoglobulin mu chain of the sheep.
Mol Immunol
; 29(7-8): 829-36, 1992.
Article
em En
| MEDLINE
| ID: mdl-1635560
ABSTRACT
A sheep cDNA library was screened with a human C mu probe, and the complete nucleotide sequence of a 1923 nt cDNA was determined. It contains sequences corresponding to all the exons (VH, DH, JH, CH1, CH2, CH3 and CH4) characteristic of the immunoglobulin mu heavy chain regions. The deduced amino acid sequence shows a percentage of identical residues in the range 65-45% when compared with the mu chains of various species. The VH region of this clone is clearly related to a group of genes that includes mouse VH36-60 and VHQ52, human VH2, VH4 and VH6 gene families and Xenopus VHII gene families. The constant region shows an unusual repartition of cystein and proline residues at the beginning of the CH2 domain, that may result in a molecule with enhanced stability and reduced flexibility.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ovinos
/
Genes de Imunoglobulinas
/
Cadeias mu de Imunoglobulina
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Mol Immunol
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
França