Patient- and facility-level factors associated with diffusion of a new antipsychotic in the VA health system.
Psychiatr Serv
; 57(1): 70-6, 2006 Jan.
Article
em En
| MEDLINE
| ID: mdl-16399965
ABSTRACT
OBJECTIVE:
When new medications are introduced, a period of diffusion, evaluation, and adoption follows. This study evaluated the influence of patient- and facility-level characteristics on the early use of a new antipsychotic, ziprasidone, among Department of Veterans Affairs (VA) patients with schizophrenia.METHODS:
Data on demographic characteristics, diagnoses, and outpatient pharmacy dispensings were obtained from the VA National Psychosis Registry for VA patients who received both a diagnosis of schizophrenia and oral antipsychotic medications during the fiscal years (FYs) 2001 (N=77,397), 2002 (N=74,724), and 2003 (N=74,399). Generalized estimating equations were used to examine associations between patient- and facility-level factors and ziprasidone use for each fiscal year.RESULTS:
In FY2001, 1.2 percent of patients used ziprasidone. Ziprasidone use more than tripled to 4.0 percent by FY2002 and more than quadrupled to 5.9 percent by FY2003. In all study years, patients who were white, younger, and female were more likely to receive ziprasidone. Patients who had previous psychiatric hospitalizations or who had diabetes were also more likely to receive ziprasidone. Differences by race diminished over time. Facility academic affiliation and region were only minimally associated with use.CONCLUSIONS:
Ziprasidone use increased rapidly among patients with schizophrenia after FDA approval, which suggests that both patients and providers remain eager to try new antipsychotic medications. Earlier dissemination was associated with clinical factors, such as comorbid diabetes, and with nonclinical factors, such as race or ethnicity. Differences by race diminished over time. The underlying processes and implications for affected patient groups are unclear.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperazinas
/
Esquizofrenia
/
Tiazóis
/
Antipsicóticos
/
Veteranos
/
Sistema de Registros
/
Tratamento Farmacológico
/
Serviços de Saúde Mental
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Psychiatr Serv
Assunto da revista:
PSIQUIATRIA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos