Platelet-activating factor stimulates production of prostaglandin E2 in murine osteoblast-like cell line MC3T3-E1.
Life Sci
; 49(15): 1103-9, 1991.
Article
em En
| MEDLINE
| ID: mdl-1654490
ABSTRACT
We found that platelet-activating factor (PAF) stimulated the production of prostaglandin (PG) E2 in MC3T3-E1 cells in a time- and dose-dependent manner. 1.0 microM PAF gave a maximal stimulation of PGE2 production by MC3T3-E1 cells after a 4 hr PAF-treatment. Furthermore, the PAF-induced PGE2 production was abolished by the pre-treatment of the cells with a PAF receptor antagonist, 1-O-hexadecyl-2-acetyl-sn-glycero-3-phospho(N,N,N-trimethyl)hexanolamine, which occupied the same receptor site as PAF. These results suggest that PAF stimulates the PGE2 synthesis through a PAF receptor mediated pathway. Possibly PAF modulates bone metabolism by stimulating PGE2 synthesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoblastos
/
Fator de Ativação de Plaquetas
/
Glicoproteínas da Membrana de Plaquetas
/
Dinoprostona
/
Receptores Acoplados a Proteínas G
Limite:
Animals
Idioma:
En
Revista:
Life Sci
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Japão