The binding of BmK IT2 on mammal and insect sodium channels by surface plasmon resonance assay.
Pharmacol Res
; 54(2): 85-90, 2006 Aug.
Article
em En
| MEDLINE
| ID: mdl-16616856
ABSTRACT
The binding of BmK IT2 to insect and mammal sodium channels was investigated by surface plasmon resonance technique. The results showed that BmK IT2 could bind not only to cockroach neuronal membranes but also to rat cerebrocortical and hippocampal synaptosomes with distinct affinity. The binding of BmK IT2 could be competed significantly by BmK AS and BmK abT, but not by AaH II, BmK I and veratridine. Furthermore, BmK alphaIV could partially inhibit the binding of BmK IT2 to rat cerebrocortical synaptosomes and cockroach neuronal membranes, but not to rat hippocampal synaptosomes. These results suggested that BmK IT2 had diverse binding properties on the mammal and insect sodium channels.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Venenos de Escorpião
/
Canais de Sódio
/
Baratas
/
Ressonância de Plasmônio de Superfície
Limite:
Animals
Idioma:
En
Revista:
Pharmacol Res
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
2006
Tipo de documento:
Article