Increase in protein kinase-C-beta-like immunoreactivity (PKC-beta-LI) in the rat superior cervical ganglion after decentralization.
Neurosci Res
; 11(4): 292-6, 1991 Sep.
Article
em En
| MEDLINE
| ID: mdl-1661878
ABSTRACT
The effect of decentralization on protein kinase-C-beta-like immunoreactivity (PKC-beta-LI) in the rat superior cervical ganglion (SCG) was studied. The cervical sympathetic trunk was transected and at different time points (0 h-14 d) after transection the rats were decapitated and the SCGs examined immunohistochemically. In the control ganglia only faint PKC-beta-LI was seen in the principal neurons, whereas several strongly immunolabelled nerve fibers were observed. In the principal ganglionic neurons PKC-beta-LI was found to be increased 1-8 days after denervation, with the maximum accumulation occurring at 4 days. Fourteen days post-transection PKC-beta-LI in the neuronal perikarya was back to the initial level, but a decrease in the number of PKC-beta-immunoreactive nerve fibers was observed. The results suggest that the amount of PKC-beta in the principal neurons of the rat SCG may be partly regulated transsynaptically by preganglionic innervation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteína Quinase C
/
Estado de Descerebração
/
Gânglios Simpáticos
Limite:
Animals
Idioma:
En
Revista:
Neurosci Res
Assunto da revista:
NEUROLOGIA
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Finlândia