[Pharmacological treatment neuromuscular impairments in critically ill patients]. / Tratamiento farmacológico de las alteraciones neuromusculares en el paciente crítico.
Nutr Hosp
; 21 Suppl 3: 114-7, 2006 May.
Article
em Es
| MEDLINE
| ID: mdl-16768038
ABSTRACT
The use of drugs for treating neuromuscular impairments that present in the patient admitted to the Intensive Care Unit is virtually inexistent. The use of intravenous immunoglobulins for managing polyneuropathy of the critically ill patient (PCIP) is supported by no evidence. More important is prophylactic therapy, as is the administration of insulin perfusion to prevent hyperglycemia that is associated to increased development of PCIP. New data suggest that the protective mechanism of this perfusion, which normalizes glucose levels, is achieved through the modulation of endothelial dysfunction and lowering levels of asymmetrical di-methyl arginine (ADMA). As for myopathy of the critically ill patient or conditions with prolonged neuromuscular blockade, treatment consists in avoiding the use of several drugs known to be associated with development of these conditions, such as muscle relaxants and aminoglycosides. In relation to acute flaccid paralysis -an infection caused by the Western Nile Virus, anecdotic cases have been reported of improvement with the use steroids or interferon, although routine management remains to be established.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polineuropatias
/
Doenças Musculares
Limite:
Humans
Idioma:
Es
Revista:
Nutr Hosp
Assunto da revista:
CIENCIAS DA NUTRICAO
Ano de publicação:
2006
Tipo de documento:
Article