Trastuzumab in metastatic breast cancer.
Eur J Gynaecol Oncol
; 27(3): 247-9, 2006.
Article
em En
| MEDLINE
| ID: mdl-16800251
ABSTRACT
Metastatic breast cancer is an incurable disease in a very high percentage of patients. Despite new progress in endocrine and other systemic therapies, this evidence remains challenging for patients and clinicians. HER2 protein is a member of the epidermal growth factor family of transmembrane receptors. HER2 is overexpressed in approximately 20% to 30% of breast cancers. Overexpression of HER2 has been shown to be associated with increased tumor proliferation and relative resistance to some types of chemotherapy and hormonal therapies. Trastuzumab, a humanized monoclonal antibody directed against HER2 protein, has been shown to be an efficacious and well tolerated treatment for HER2-overexpressing metastatic breast cancer, both as a single agent and when it is used in combination with chemotherapy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Anticorpos Monoclonais
Limite:
Female
/
Humans
Idioma:
En
Revista:
Eur J Gynaecol Oncol
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Itália