Direct and indirect effects of hedgehog pathway activation in the mammalian retina.
Mol Cell Neurosci
; 32(3): 274-82, 2006 Jul.
Article
em En
| MEDLINE
| ID: mdl-16815712
ABSTRACT
The morphogen Sonic hedgehog (Shh) is expressed by the projection neurons of the retina, retinal ganglion cells (RGCs) and promotes retinal precursor cell (RPC) proliferation. To distinguish between direct and indirect effects of Hedgehog (Hh) pathway activation in the perinatal mouse retina, we followed the fate of cells that expressed a constitutively active allele of Smoothened (SMO-M2), the signal transduction component of the Hh pathway. SMO-M2 expression promoted a cell-autonomous increase in CyclinD1 expression and RPC proliferation and promoted the development of cells with an inner nuclear layer identity. SMO-M2 expression also inhibited rhodopsin expression in uninfected cells, thus highlighting an unexpected non-cell autonomous effect of Hh pathway activation on photoreceptor development.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Retina
/
Transdução de Sinais
/
Transativadores
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Mol Cell Neurosci
Assunto da revista:
BIOLOGIA MOLECULAR
/
NEUROLOGIA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Canadá