Veto-like down-regulation of T helper cell reactivity in vivo by injection of semi-allogeneic spleen cells.
Immunol Lett
; 29(3): 223-7, 1991 Aug.
Article
em En
| MEDLINE
| ID: mdl-1685148
ABSTRACT
Injection of semiallogeneic (C57BL/6 X BALB/c) F1 MHC class II expressing spleen cells into C57BL/6 mice leads to a clonal deletion or anergy of recipient CD4+ T helper cells with specificity for the allogeneic MHC class II molecules on the injected cells whereas reactivity against third party allogeneic cells is not influenced. These observations were based on analyses in the recipient mice of proliferating CD4+ T cells in mixed lymphocyte reactions (MLR), limiting dilution (LD) cultures and measurements of IL-2 and IL-3 secretion.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Baço
/
Linfócitos T CD4-Positivos
/
Regulação para Baixo
/
Linfócitos T Auxiliares-Indutores
Limite:
Animals
Idioma:
En
Revista:
Immunol Lett
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Dinamarca