The attenuation effect of chlorpromazine on electro-acupuncture analgesia: involvement of dopamine system.
Acupunct Electrother Res
; 16(3-4): 101-9, 1991.
Article
em En
| MEDLINE
| ID: mdl-1685618
ABSTRACT
The effect of chlorpromazine (CPZ) (0.1 or 0.5 mg/kg, iv) on electroacupuncture analgesia (EAA) was examined by using potassium dolorimetry in rabbits. CPZ itself induced hyperanalgesia, whereas it attenuated EAA in terms of maximal increase of pain threshold as well as EAA after effect. Therefore, CPZ is not a good candidate for enhancing EAA in clinics. Monoamines and their metabolites in cerebrospinal fluid (CSF) of the rabbits were detected by high pressure liquid chromatography coupled to electrochemical detector (HPLC-ECD) method. It was revealed that CPZ enhanced DOPAC and HVA contents in CSF in both the presence and absence of electroacupuncture. CPZ attenuated EAA with elevations of DOPAC and HVA concentration in CSF. There was a positive correlation between the increases of DOPAC and HVA contents in CSF and attenuation effect of CPZ on EAA. These results suggested that activation of dopamine system be unfavorable for EAA.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Monoaminas Biogênicas
/
Analgesia por Acupuntura
/
Eletroacupuntura
/
Clorpromazina
/
Manejo da Dor
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Acupunct Electrother Res
Ano de publicação:
1991
Tipo de documento:
Article