Pharmacokinetics and brain entry of alaptide, a novel nootropic agent, in mice, rats and rabbits.
J Pharm Pharmacol
; 43(12): 874-6, 1991 Dec.
Article
em En
| MEDLINE
| ID: mdl-1687590
ABSTRACT
Pharmacokinetics of a novel nootropic agent, alaptide, have been examined in plasma and brain of mice, rats and rabbits following an intravenous dose (1 mg kg-1). First-order equilibration rate constants between plasma and brain (kBO) were calculated by a two-compartment model with a linked compartment (brain). Brain alaptide equilibrates rapidly with the central compartment in mice and rats due to the high kBO/beta ratio. In rabbits the equilibration is much slower (kBO/beta approximately 1). Partition coefficients between brain and plasma calculated from areas under the brain and plasma concentration-time curves, are 0.479, 0.549 and 0.864, in mice, rats and rabbits, respectively.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos Cíclicos
/
Psicotrópicos
/
Neuropeptídeos
Limite:
Animals
Idioma:
En
Revista:
J Pharm Pharmacol
Ano de publicação:
1991
Tipo de documento:
Article