Aza-stilbenes as potent and selective c-RAF inhibitors.
Bioorg Med Chem Lett
; 16(20): 5378-83, 2006 Oct 15.
Article
em En
| MEDLINE
| ID: mdl-16890436
ABSTRACT
The synthesis of several novel aza-stilbene derivatives was carried out. The compounds were tested for their c-RAF enzyme inhibition. Compound 27 possesses significant potency against c-RAF and demonstrates selectivity over other protein kinases. A hypothesis for the binding mode, activity, and selectivity is proposed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estilbenos
/
Compostos Aza
/
Proteínas Proto-Oncogênicas c-raf
/
Inibidores de Proteínas Quinases
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos