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Vaccination with melanoma lysate-pulsed dendritic cells, of patients with advanced colorectal carcinoma: report from a phase I study.
Burgdorf, S K; Fischer, A; Claesson, M H; Kirkin, A F; Dzhandzhugazyan, K N; Rosenberg, J.
Afiliação
  • Burgdorf SK; Department of Surgical Gastroenterology, University Hospital of Copenhagen, Denmark. stebur01@gentoftehosp.kbhamt.dk
J Exp Clin Cancer Res ; 25(2): 201-6, 2006 Jun.
Article em En | MEDLINE | ID: mdl-16918131
ABSTRACT
Immune therapy have shown new and exciting perspectives for cancer treatment. Aim of our study was to evaluate toxicity and possible adverse effects from vaccination of patients with advanced colorectal cancer with autologous dendritic cells (DC) pulsed with lysate from a newly developed melanoma cell line, DDM-1.13. Six patients were enrolled in the phase I trial. Autologous DCs were generated in vitro from peripheral blood monocytes in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4). DCs were pulsed with melanoma cell lysate from a cloned and selected melanoma cell line enriched in expression of MAGE-A antigens and deficient in expression of melanoma differentiation antigens tyrosinase, MART-1 and gp100. Vaccinations were administered intradermally on the proximal thigh with a total of five given vaccines at 2 weeks intervals. Each vaccine contained 3-5 x 10(6) DCs. Five of the six patients received all five vaccines. The treatment was well tolerated in all patients without any observed vaccine-correlated adverse effects. Treatment with this DC-based cancer vaccine proved safe and non-toxic.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Células Dendríticas / Neoplasias Colorretais / Vacinas Anticâncer / Melanoma / Antígenos de Neoplasias Limite: Adult / Aged / Humans / Middle aged Idioma: En Revista: J Exp Clin Cancer Res Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Dinamarca
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Células Dendríticas / Neoplasias Colorretais / Vacinas Anticâncer / Melanoma / Antígenos de Neoplasias Limite: Adult / Aged / Humans / Middle aged Idioma: En Revista: J Exp Clin Cancer Res Ano de publicação: 2006 Tipo de documento: Article País de afiliação: Dinamarca