Neonatal outcome in polycystic ovarian syndrome patients treated with metformin during pregnancy.
J Matern Fetal Neonatal Med
; 19(7): 415-9, 2006 Jul.
Article
em En
| MEDLINE
| ID: mdl-16923696
ABSTRACT
OBJECTIVE:
The present study aimed to evaluate the effect of metformin exposure during pregnancy on neonates of polycystic ovarian syndrome (PCOS) patients.METHOD:
Neonatal outcomes of 33 women with PCOS treated with metformin during pregnancy were compared to neonatal outcomes of 66 normal healthy women in a retrospective case-control study.RESULTS:
The mean birth weight percentile of neonates exposed to metformin in utero during the first trimester was significantly lower than that of neonates delivered to normal healthy matched controls. After controlling for pregnancy complications, this observation became only marginally statistically significant.CONCLUSION:
Although metformin is an attractive option for induction of ovulation in PCOS patients, there is a need for more evidence related to its safety during pregnancy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome do Ovário Policístico
/
Complicações na Gravidez
/
Peso ao Nascer
/
Hipoglicemiantes
/
Metformina
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Newborn
/
Pregnancy
Idioma:
En
Revista:
J Matern Fetal Neonatal Med
Assunto da revista:
OBSTETRICIA
/
PERINATOLOGIA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Israel