An immunoglobulin light chain from a lupus-prone mouse induces autoantibodies in normal mice.
J Exp Med
; 171(6): 1919-30, 1990 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-1693654
ABSTRACT
Autoantibodies against the 70-kD U1 RNP nucleoprotein autoantigen and DNA were elicited in normal BALB/c mice with a purified Ig light chain. This light chain, derived from a lupus-prone MRL-lpr/lpr mouse, has two distinctive properties it contains an idiotypic marker recognized by a monoclonal MRL-lpr/lpr anti-snRNP autoantibody, and the amino acid sequence of its third hypervariable region (CDR3) is homologous to a sequence in an antigenic region of the 70-kD U1 RNP polypeptide. The results demonstrate that an Ig idiotype that mimics an autoantigen can induce autoimmunization.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Cadeias Leves de Imunoglobulina
/
Lúpus Eritematoso Sistêmico
Limite:
Animals
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
1990
Tipo de documento:
Article