CD8-positive T cell-induced liver damage was found in a patient with polymyositis.
Intern Med
; 45(18): 1059-63, 2006.
Article
em En
| MEDLINE
| ID: mdl-17043378
ABSTRACT
We describe a case of polymyositis (PM) with liver injury that occurred in a patient with rheumatoid arthritis (RA). A 74-year-old woman who had a 12-year history of RA was admitted to our hospital because of muscle weakness and liver dysfunction. CD8-positive T cell infiltration was found in the interstitium of both the liver and muscle. In addition to the administration of a large amount of prednisolone (PSL), high-dose intravenous immunoglobulin (IVIG) successfully improved myositis and hepatitis. Our case indicates the pathogenic potential of CD8-positive T cells in PM-associated liver injury.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimiosite
/
Linfócitos T CD8-Positivos
/
Hepatopatias
Limite:
Aged
/
Female
/
Humans
Idioma:
En
Revista:
Intern Med
Assunto da revista:
MEDICINA INTERNA
Ano de publicação:
2006
Tipo de documento:
Article